Articles and Books
Case Reports
An Enzyme-based Nutritional Protocol in Metastatic Cancer: Case Reports of a Patient with Colon Cancer and a Patient with Lung Cancer. Alternative Therapies in Health and Medicine, 25(4):16-19, 2019. PMID 31202206.
Linitis Plastica Gastric Cancer: A Case Report. Townsend Letter, Aug/Sep 2016:68-69.
Gonzalez NJ, Isaacs LL. The Gonzalez Therapy and Cancer: a Collection of Case Reports. Alternative Therapies in Health and Medicine, 13(1):46-55, 2007. PMID 17283741. There are 31 cases, beginning on page 4.
Gonzalez NJ, Isaacs LL. “Evaluation of Pancreatic Proteolytic Enzyme Treatment of Adenocarcinoma of the Pancreas, With Nutrition and Detoxification Support.” Nutrition and Cancer, 33(2): 117-124, 1999. PMID: 10368805. Click here for the abstract. Subscribe to the announcement list and get a PDF of the article.
Evaluating Anecdotes and Case Reports. Alternative Therapies in Health and Medicine, 13(2):36-8, 2007. PMID 17405677.
Theory
Pancreatic Proteolytic Enzymes and Cancer: New Support for an Old Theory. Integrative Cancer Therapies, 21:15347354221096077, 2022. PMID: 35514109.
Pancreatic Enzymes: Not Just for Digestion. Price-Pottenger Journal, 45(4):4-13, 2021. In addition to the article by Dr. Isaacs, there are interviews of three of her patients.
Pancreatic Proenzymes and Primitive Cells, Townsend Letter, August/September 2022.
A Brief History of Glandular Therapy: More than Just Thyroid. Integrative Medicine: A Clinician's Journal, 22(2):26-31, 2023. PMID 37363152.
Glandular Supplements Explained. Price-Pottenger Journal, 47(3):12-19,2023.
Coffee Enemas: A Narrative Review. Alternative Therapies in Health and Medicine, 27(3):46-49, 2021. PMID 33711817.
Foreword to Nutrition and the Autonomic Nervous System by Nicholas J. Gonzalez, M.D. Click here for the Foreword; click here for the book listing on Amazon (affiliate link).
Gonzalez NJ, Isaacs LL. The Trophoblast and the Origins of Cancer: One solution to the medical enigma of our times. ISBN: 978-0-9821965-0-2. Available through Amazon (affiliate link).
Gonzalez NJ, Isaacs LL. Statistics: Why Meaningful Statistics Cannot Be Generated from a Private Practice. Alternative Therapies in Health and Medicine, 21(2): 11-15, 2015. PMID: 25830274.
Isaacs LL. Dr. Franklin Shively's Multiple Proteolytic Enzyme Therapy of Cancer. Dr. Shively treated patients with intravenous enzymes in the 1950s and 1960s. The Townsend Letter published Dr. Isaacs' review of his book in their November 2021 issue.
History
Research Battles: Survival Tips From a Veteran. Integrative Medicine: A Clinician's Journal, 14(5):30-2, 2015. PMID 26770164. A discussion of the mismanaged clinical trial comparing enzyme treatment with chemotherapy for patients with pancreatic cancer, focusing on the errors in the design of the study.
Opposition from Physicians and the Media: As the clinical trial was beginning to enroll patients in 2000, a hostile article appeared in a national newspaper. Could it have affected adherence by study participants?
The Gonzalez Best Case Series Presentation to the NCI: 25 Cases, 25 Years Later. Alternative Therapies in Health and Medicine, 25(4):12-14, 2019. PMID 31202205. This is a slightly modified version of the Foreword Dr. Isaacs wrote for the publication of the monograph Dr. Gonzalez prepared for his presentation at the National Cancer Institute.
Nicholas Gonzalez: Quack or Pioneer? An open response to Lancet Oncology
Tributes to Nicholas J. Gonzalez, M.D.
Dr. Gonzalez as a Practice Colleague: A Memoir: Alternative Therapies in Health and Medicine published Dr. Isaacs' tribute to Dr. Gonzalez in their July/August 2016 issue.
In Memoriam: Nicholas J. Gonzalez, MD: This article was published in the January 2016 issue of the Townsend Letter.
